Drosophila Migration Gene Screens
Genes encoding cytoskeleton-associated proteins enriched in migratory cells
The genes in the table below were assembled by searching the Affymetrix-assigned GO terms (biological process, cellular component and molecular function) associated with each of the migratory cell enriched genes for the terms "cytoskeleton" or "actin". This list is not identical to the list of genes associated with the cytoskeleton in the GO-Slim function of Genespring (See Experimental procedures). Abbreviations: ADF-actin depolymerizing factor domain, CH-Calponin homology, PH-Plextrin homology, SH3- src homology 3, PTP-protein tyrosine phosphatase, CAP-cytoskeleton associated protein, MYSc-Myosin motor domain.
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| Gene | Description | Nearest mammalian (Human) homolog | Fold Change | |
| 1 | Act42A GeneID:35526 Entrez Flybase | Actin 42A Proposed Function: Actin subunit Conserved Protein Domains: Actin | ACTG2 GeneID: 72 CMKB Orthologs | |
| 2 | Act5C GeneID:31521 Entrez Flybase | Actin 5C Proposed Function: Actin subunit Conserved Protein Domains: Actin | ACTG1 GeneID: 71 CMKB Orthologs | |
| 3 | Act79B GeneID:40444 Entrez Flybase | Actin79B Proposed Function: Actin subunit Conserved Protein Domains: Actin | ACTA2 GeneID: 59 CMKB Orthologs | |
| 4 | Actn GeneID:31166 Entrez Flybase | alpha-actinin Proposed Function: F-actin crosslinking Links talin and F-actin Conserved Protein Domains: CH, EF hand, Spectrin repeats | ACTN1 GeneID: 87 CMKB Orthologs | |
| 5 | alpha-Cat GeneID:40517 Entrez Flybase | Alpha catenin Proposed Function: Cell adhesion/ actin binding Conserved Protein Domains: Vinculin family | CTNNA2 GeneID: 1496 CMKB Orthologs | |
| 6 | AnnIX GeneID:42492 Entrez Flybase | Annexin IX Proposed Function: Membrane organization Conserved Protein Domains: Annexin repeats | ANXA11 GeneID: 311 CMKB Orthologs | |
| 7 | AnnX GeneID:33019 Entrez Flybase | Annexin X Proposed Function: Membrane fusion and actin binding Conserved Protein Domains: Annexin X | ANXA6 GeneID: 309 CMKB Orthologs | |
| 8 | arm GeneID:31151 Entrez Flybase | Armadillo Proposed Function: Adaptor / cell adhesion / transcription Conserved Protein Domains: Arm repeats | CTNNB1 GeneID: 1499 CMKB Orthologs | |
| 9 | Arp66B GeneID:38898 Entrez Flybase | Actin related protein Proposed Function: Actin filament nucleation and branching Conserved Protein Domains: actin | ACTR3 GeneID: 10096 CMKB Orthologs | |
| 10 | Arp87C GeneID:41566 Entrez Flybase | Actin related protein Proposed Function: Actin filament nucleation and branching Conserved Protein Domains: actin | ACTR1A GeneID: 10121 CMKB Orthologs | |
| 11 | Arpc3A GeneID:41917 Entrez Flybase | Actin related protein C3a Proposed Function: Actin filament nucleation and branching Conserved Protein Domains: P21 arc | ARPC3 GeneID: 10094 CMKB Orthologs | |
| 12 | beta_Spec GeneID:32746 Entrez Flybase | beta-Spectrin Proposed Function: Actin binding, phospholipid binding Membrane skeleton Conserved Protein Domains: CH, PH, Spectrin repeats | SPTBN1 GeneID: 6711 CMKB Orthologs | |
| 13 | BicD GeneID:35051 Entrez Flybase | Bicaudal D Proposed Function: MT and vesicle binding Conserved Protein Domains: Smc | BICD1 GeneID: 636 CMKB Orthologs | |
| 14 | CAP GeneID:36084 Entrez Flybase | Rexin Proposed Function: Adaptor Conserved Protein Domains: SH3 | CMKB Orthologs | |
| 15 | CG10083 GeneID:39520 Entrez Flybase | None Proposed Function: Competes with tropomyosin for F-actin binding Conserved Protein Domains: ADF, SH3 | DBNL GeneID: 28988 CMKB Orthologs | |
| 16 | CG10540 GeneID:37387 Entrez Flybase | Capping protein alpha Proposed Function: Barbed end actin capping Conserved Protein Domains: F-actin_cap_A | CAPZA1 GeneID: 829 CMKB Orthologs | |
| 17 | CG11242 GeneID:37244 Entrez Flybase | none Proposed Function: Cytoskeleton-associated / tubulin chaperone Conserved Protein Domains: CAP-GLY | TBCB GeneID: 1155 CMKB Orthologs | |
| 18 | CG11605 GeneID:43997 Entrez Flybase | jitterbug Proposed Function: F-actin crosslinking Conserved Protein Domains: Filamin type Ig | CMKB Orthologs | |
| 19 | CG31352 GeneID:261629 Entrez Flybase | none Proposed Function: Actin binding Conserved Protein Domains: 4X Lim,Villin | ABLIM1 GeneID: 3983 CMKB Orthologs | |
| 20 | CG3960 GeneID:31591 Entrez Flybase | none Proposed Function: Actin binding Conserved Protein Domains: CH | CMKB Orthologs |